Renowned mushroom researcher follows call to Jena: Hans Knöll institute Jena creates new research department

Professor Dr. Bernhard Hube (openPR) - Jena, 4 December 2006 - which takes over recognized scientist Dr. Bernhard Hube in the area of the research at disease-causing yeasts internationally at the beginning of the yearly 2007 the line of the again created department of Mikrobielle Pathogenitätsmechanismen at the Leibniz institute for natural substance research and infection biology - Hans Knöll institute - and its past research here will resume and will deepen. At the same time it follows thereby a call of the Friedrich Schiller Universtät Jena (FSU) and occupies there the chair Mikrobielle Pathogenität.

Acknowledgment attained the scientist particularly by investigations over sekretorische Proteasen of the yeast mushroom Candida albicans. These enzymes make possible to survive the mushroom on surfaces of the landlord and penetrate into deeper fabrics and organs. Bernhard Hube could isolate the hereditary factors for such enzymes. It was thereby first which it succeeded to characterize a Virulenz gene in such a way specified with Candida albicans. Virulenz genes contain the building guidance for protein materials, which are responsible for the disease-causing characteristics of the mushroom. The understanding of the Pathogenitätsmechanismen - as mushrooms make ill - is basis for the development of medicines against these so far with difficulty fightable mushroom infections.

Bernhard Hube researched six years at Robert institute for cook in Berlin. There it led the group of new generations of Pathogenitätsfaktoren with mushroom infections and was last director/conductor of the field of activity Mykologie. As a private lecturer he taught microbiology at the free university to Berlin. Following its study of the microbiology at the university Goettingen there and also at the University of Hamburg as scientific coworkers actively was it. Before it was likewise habilitiert at the University of Hamburg, Bernhard Hube researched three years at the British University of Aberdeen as Honour Research Fellow.

Dr. Michael ram
Scientific organization
Leibniz institute for natural substance research and infection biology registered association.
- Hans Knöll institute -
Hiving mountain route 11a
07745 Jena
Tel.: 03641/65 66 42
Fax: 03641/65 66 20
michael.ramm@hki-jena.de
Press service: pr@hki-jena.de
www.presse.hki-jena.de

Hans Knöll institute offers best research conditions

The Hans Knöll institute in Jena is Germany far the only mechanism, which concerns itself particularly with pilzlichen pathogens and the search for new medicines against mushroom infections. Professor Hube belongs in this area to the internationally leading researchers. At the Jenaer Institut can it and its team now still more comprehensively with their most important future project be occupied: By investigation of the entire gene COM von Candida albicans those genes are to be identified, which are switched on with a mushroom infection. Thus in the future new starting points for more effective medicines can be found.

Candida albicans is one of the medically most important mushrooms with world-wide spreading. With healthy humans the mushroom causes no damage, can however with defense-weakened persons superficial infections above all the mucous membranes release. For patients, whose immune system is strongly weakened for example by an HIV infection, cancer or also by Transplantation, an infection can have life-threatening effects by Candida albicans. Mechanisms, which steer round the actually harmless microorganism to a dangerous pathogen, are at present investigated intensively. The suppression of such switching processes by new medicines could in the future contribute to therapieren Candida infections better. The quality of life of HIV infecting or humans with organ transplants could be improved in this way clearly.

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